Remote ischaemic preconditioning in intermittent claudication
نویسندگان
چکیده
منابع مشابه
Remote ischemic preconditioning in patients with intermittent claudication
OBJECTIVE Remote ischemic preconditioning (RIPC) is a phenomenon in which a short period of sub-lethal ischemia in one organ protects against subsequent bouts of ischemia in another organ. We hypothesized that RIPC in patients with intermittent claudication would increase muscle tissue resistance to ischemia, thereby resulting in an increased ability to walk. METHODS In a claudication clinic,...
متن کاملCardioprotection by remote ischaemic preconditioning.
Perioperative myocardial infarction is a leading cause of morbidity and mortality after major non-cardiac surgery. Pharmacological agents such as beta-blockers may reduce the risk but are associated with side-effects and may be contra-indicated in some patients. Basic scientific experiments and preliminary clinical trials in humans suggest that remote ischaemic preconditioning (RIPC), where bri...
متن کاملRemote ischaemic preconditioning: closer to the mechanism?
Brief periods of ischaemia followed by reperfusion of one tissue such as skeletal muscle can confer subsequent protection against ischaemia-induced injury in other organs such as the heart. Substantial evidence of this effect has been accrued in experimental animal models. However, the translation of this phenomenon to its use as a therapy in ischaemic disease has been largely disappointing wit...
متن کاملTime for reassessment of remote ischaemic preconditioning.
Ischaemia–reperfusion (IR) injury is a recognized cause of perioperative morbidity and mortality affecting a wide range of surgical procedures, but particularly cardiovascular surgery. Over the past 30 years a large body of published animal and clinical research has suggested that ischaemic preconditioning (IPC), consisting of a limited ischaemic insult applied before the expected major ischaem...
متن کاملIntermittent claudication
Peripheral arterial disease is a common health problem that globally affects over 200 million individuals, and intermittent claudication (IC) is the most common symptomatic presentation. The leg symptoms in IC are provoked by walking exercise and can be alleviated by medical intervention, exercise training and invasive vascular interventions (revascularization). The quality of evidence for inva...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases
سال: 2015
ISSN: 1875-2136
DOI: 10.1016/j.acvd.2015.03.004